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San Diego University of California Scientists Find a Way to Slow Ageing Cycle

Getting old is unavoidable but scientists at San Diego University of California (UCSD) could be one step closer. It is to be able to slow the cycle of ageing. A team of scientists researched yeast ageing — chosen because its cells are easily controlled — to try to understand why and for the same reason, different cells mature at the same rate.

Their results were fascinating. According to the scientists who published their results in the journal Science, also cells made from the same genetic materials and within the same setting aged in “strikingly distinct ways.” The scientists discovered that half of the yeast cells aged because of a progressive decline in the nucleolus, a circular body found in a cell nucleus, using techniques including microfluidics and computer modelling.

Nevertheless, the other half agreed due to a mitochondrial malfunction, which generates the energy of a cell. Scientists said the cells walk one of two routes — nuclear or mitochondrial. Early in life, and proceed down the ageing path until they gradually fail and die. Further experiments carrying out by researchers to understand how the cells were behaving.

The research team, after modelling the “ageing environment,” found they could control — and optimize — the ageing cycle, using computer simulations to reprogram the master circuit and adjust its DNA. Instead, with a significantly extended lifespan, they were able to construct a “novel ageing path.”

This, according to researchers, could potentially contribute to the possibility of slowing human ageing.

Scientists said they’re planning to test their model in complex cells, animals, and ultimately humans. It is as well as exploring how therapeutic and drug combinations could lead to a longer lifespan.

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